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. 2018 May 16;11:155. doi: 10.3389/fnmol.2018.00155

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Copyright © 2018 Lu, Chen, Zheng, Li, Wang, Liu, Shi and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ICA inhibited the neuroinflammation in LID after 6-OHDA-induced DA neuronal damage. The protein levels of neuroinflammatory factors, such as COX-2, IL-1β and TNF-α, in the SN were detected 7 (A) and 21 (B) days after daily L-DOPA (25 mg/kg, i.p.) combined with ICA (20 mg/kg, p.o.) treatment by western blotting. Data were shown as mean ± SEM from six rats (n = 6). *p < 0.05 compared with the control group; ^#p < 0.05 compared with 6-OHDA-treated group; ^ψp < 0.05 compared with 6-OHDA+L-DOPA group.