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. 2018 May 22;8:7993. doi: 10.1038/s41598-018-26287-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Group comparison of BOLD time courses, signal amplitude, rising slopes, and response latency during tactile versus FUS stimulation in different brain regions. (A) Normalized BOLD time courses (peak is considered as 1) derived from eight activated regions (by either tactile stimulation or FUS) and two control conditions: white matter (WM) region and at resting state. Shadows indicate the standard error distribution. Light pink background strips indicate the 30-sec stimulation period. (B) Comparison of absolute peak BOLD% signal changes evoked by tactile stimulation versus FUS in each individual ROI. *p < 0.05, **p < 0.01, ***p < 0.005, ****p < 0.001, unpaired t-test. (C) Rearranged normalized BOLD signal changes plot (signal of areas 3a/3b is considered as 1) from high to low for tactile stimulation and corresponding values for FUS. *p < 0.05, **p < 0.01, nonparametric Mann-Whitney test. (D) Direct comparisons of 50% peak latency in each ROI. **p < 0.01, unpaired t-test. FMRI data from a total of 13 tactile and 19 FUS runs from six imaging sessions in two animals were included in the group quantification.