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. 2018 May 22;8:7993. doi: 10.1038/s41598-018-26287-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MRI guided FUS stimulation set up. (A) 3D view of the spatial relationships of the FUS transducer location, estimated beam path using the optically-guided real-time projection of the freefield beam, and the targeted brain region. (B–D) Overlaid free field FUS beam on MRI images on three different imaging planes (B: coronal, C: axial, D: sagittal). (E) PUS pulse design. Color bars represent the scaled pressure range.