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. 2018 May 22;9(6):590. doi: 10.1038/s41419-018-0670-2

Fig. 3. Mortality, liver histopathology in LPS/D-GalN-induced liver failure mice treated with/without GSK126.

Fig. 3

a It was presented that the mortality of LPS/D-GalN-induced liver failure mice treated with DMSO (n = 16) or GSK126 (n = 14). b, c In DMSO+PBS and GSK126+LPS/D-GalN groups, alive mice from were sacrificed at the observation end point of 24 h, and the liver were collected. In DMSO+LPS/D-GalN group, mice dead at 6 h with collection of the liver tissue. The livers from the three groups at the observation end point or dead point were subjected for HE staining, with bleeding and infiltration degree analysis. HPF high-power field; ***, P < 0.001 (b). The livers from the DMSO+LPS/D-GalN and GSK126+LPS/D-GalN groups were further subjected for TUNEL staining (c). Three independent experiments were performed with similar results