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. 2018 May 22;9(6):590. doi: 10.1038/s41419-018-0670-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Mice were sacrificed in 1 h after injection of PBS or LPS/D-GalN, and the Kupffer cells from liver tissues were collected. a Genomic DNA fragments covering the −1.5 to +1.5 kb region for Tnf relative to the transcription start site for PCR analysis are indicated. ChIP assay was performed in the Kupffer cells to analyse H3K27me3 statuses (b) and EZH2 affinity (c) on the Tnf promoter region, and H3K27me3 statuses on Tgf-β1 promoter region (d). The bars represented bands density ratios of H3K27me3/input enrichment. *, P < 0.05; **, P < 0.01; ***, P < 0.001