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. 2018 May 22;9(6):595. doi: 10.1038/s41419-018-0506-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Human islets were pre-treated ±1 μM Fer-1 or ±100 μM DFO for 24 h and subsequently challenged ±50 μM erastin for an additional 24 h. Subsequent to culture, islets were collected and assessed for sGSIS. Cell-free supernatants were assessed for insulin secretion via ELISA and expressed as stimulation index (insulin secreted in response to 16.7 mM glucose vs. insulin secreted in response to 2.8 mM glucose). Data represented as mean ± SEM, triplicate samples from at least three human pancreata. **p < 0.01 (one-way ANOVA, followed by Tukey’s multiple comparison test)