Fig. 2.

In initial bone biopsy, the tumor was composed of differentiated plasma cells (A), which were positive for CD138 (B), but negative for CD3 (C). (D) The tumor cells were positive for Epstein-Barr virus-encoded RNA (EBER) in situ hybridization. (E) In relapsed soft tissue biopsy, the tumor was composed of medium-sized blastic cells admixed with smaller plasmacytic cells. Most of the tumor cells were strongly positive for CD138 (F) and CD3 (G). (H) The tumor cells were also positive for EBER ISH.