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Comparison of EGFR mutations detected by targeted NGS and PNA-clamping PCR
| Sample type | No. of cases compared | Concordant (NGS/PNA) |
Discordant (NGS/PNA) |
Concordance (%) | |||
|---|---|---|---|---|---|---|---|
| –/– | +/+ | –/+ | +/– | +/+ | |||
| FFPE | 131 | 69 | 53 | 2 | 6 | 1 | 93.1 |
| FF | 14 | 5 | 7 | 1 | 1 | 0 | 85.7 |
| Total | 145 | 74 | 60 | 3 | 7 | 1 | 92.4 |
EGFR, epidermal growth factor receptor; NGS, next-generation sequencing; PNA, peptide nucleic acid; PCR, polymerase chain reaction; FFPE, formalin-fixed paraffin-embedded; FF, fresh frozen.
