Table 4.
Comparison of diagnostic categories between conventional PTC, NIFTP/EFVPTC, and infiltrative FVPTC
| FNAC diagnostic category | Conventional PTC | NIFTP/EFVPTC | Infiltrative FVPTC | p-valuea | p-valueb | p-valuec |
|---|---|---|---|---|---|---|
| Non-diagnostic | 32 (2.2) | 5 (7.1) | 5 (7.7) | .025 | 1.000 | .016 |
| Benign | 6 (0.4) | 9 (12.9) | 1 (1.6) | < .001 | .019 | .259 |
| AUS | 144 (10.0) | 31 (44.3) | 25 (40.3) | < .001 | .646 | < .001 |
| AUS-NA | 135 (9.3) | 20 (28.6) | 21(33.9) | < .001 | .511 | < .001 |
| AUS-MF | 3 (0.2) | 10 (14.3) | 4 (6.4) | < .001 | .167 | < .001 |
| AUS-HC | 0 (0) | 0 (0) | 0 (0) | 1.000 | 1.000 | 1.000 |
| AUS-others | 6 (0.4) | 1 (1.4) | 0 (0) | .282 | 1.000 | 1.000 |
| Follicular neoplasm | 0 (0) | 4 (5.7) | 1 (1.6) | < .001 | .370 | .041 |
| Suspicious for malignancy | 339 (23.5) | 13 (18.6) | 14 (22.6) | .344 | .569 | .873 |
| Malignant | 924 (63.9) | 8 (11.4) | 16 (25.8) | < .001 | .033 | < .001 |
Values are presented as number (%).
PTC, papillary thyroid carcinoma; NIFTP, noninvasive follicular thyroid neoplasm with papillary-like nuclear features; EFVPTC, encapsulated follicular variant of papillary thyroid carcinoma; FVPTC, follicular variant of papillary thyroid carcinoma; FNAC, fine-needle aspiration cytology; AUS, atypia of undetermined significance; NA, nuclear atypia; MF, microfollicles; HC, Hurthle cells.
a
Conventional PTC vs. NIFTP/EFVPTC;
b
NIFTP/EFVPTC vs. infiltrative FVPTC;
c
Conventional PTC vs. infiltrative FVPTC.