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. 2018 Mar 26;9:1228. doi: 10.1038/s41467-018-03566-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Microglia do not phagocytose dendritic spines. Representative images of microglia (red, Cx3cr1::CreER; RC::LSL-tdTomato) a apposing or b encapsulating a dendritic spine (green, Thy1::EGFP; white insert: projection of the undeconvolved z-stack containing the contacted spine). Note that the neck of the contacted spine is intact (white arrow head). c Quantification of microglia–spine contacts. No spine was found phagocytosed, as contacted spines were always attached to their dendrite (n = 25 cells from 5 animals for 8944 spines analyzed, error bars are mean + SEM). d Encapsulated spine localizing next to a phagocytic compartment (blue, CD68 immunostaining). Scale bars: 0.5 µm