Table 3.
Association of antidepressant prescription with increase in body mass index (BMI) category. Values are frequencies unless stated otherwise
| Variables | Initial BMI category (kg/m2)* | ||||
|---|---|---|---|---|---|
| 18.5-24.9 | 25.0-29.9 | 30.0-34.9 | 35.0.39.9 | 40.0-44.9 | |
| No antidepressant: | |||||
| Person years | 264 728 | 309 434 | 297 714 | 275 752 | 192 405 |
| Increase in BMI category | 14 940 | 18 440 | 20 205 | 21 824 | 16 337 |
| Antidepressant: | |||||
| Person years | 50 763 | 64 152 | 73 014 | 78 907 | 66 040 |
| Increase in BMI category | 3751 | 5265 | 6562 | 8028 | 7095 |
| Unadjusted rate ratio (95% CI) | 1.31 (1.26 to 1.36) | 1.38 (1.34 to 1.42) | 1.32 (1.29 to 1.36) | 1.29 (1.25 to 1.32) | 1.27 (1.23 to 1.30) |
| Adjusted rate ratio (95% CI)† | 1.29 (1.25 to 1.34) | 1.29 (1.25 to 1.33) | 1.23 (1.19 to 1.26) | 1.22 (1.19 to 1.25) | 1.21 (1.17 to 1.24) |
*
163 542 person years were accounted for by initial BMI categories of <18.5 or ≥45.0.
†
Adjusted for age, sex, depression recording, comorbidity, coprescribing of antiepileptics or antipsychotics, deprivation, smoking, and advice on diet.