Figure 6.

Hepatic mitochondrial membrane potential, (A), ATP content (B) and mitochondrial DNA (MtDNA) damage (C) in 8-week-old offspring rats. The result about mitochondrial membrane potential and ATP content is expressed as % control, however, MtDNA damage is represented as “fold increase” over the controls in mitochondrial common deletion. The data are presented as the mean ± SEM. n = 6 in each group. ^*P < 0.05, ^**P < 0.01 vs. control, ^§P < 0.05, ^§§P < 0.01 vs. LPS group, ^#P < 0.05, ^##P < 0.01 vs. HFD group (One-way ANOVA). Con group, male offspring rats treated with prenatal saline and postnatal normal diet from 4 to 8 weeks old; LPS group, male offspring rats treated with prenatal LPS and postnatal normal diet from 4 to 8 weeks old; HFD group, male offspring rats treated with prenatal saline and postnatal high fat diet from 4 to 8 weeks old; L+H group, male offspring rats treated with prenatal LPS and postnatal high fat diet from 4 to 8 weeks old.