Table 2.
Univariate and multivariate analyses for prognostic factors affecting OS in CRC.
| Risk factors | Univariate analysis | Risk factors | Multivariate analysis | ||
|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | ||
| Menopause status: menopause | 2.437 (0.879–6.756) | 0.087 | Menopause status: menopause | 3.381 (1.062–10.759) | 0.039 |
| Ratio of signet cells: high | 4.655 (1.366–15.863) | 0.014 | Ratio of signet cells: high | 2.301 (0.613–8.641) | 0.217 |
| Tumor PD-L1 expression: negative | 5.129 (1.567–16.791) | 0.007 | Tumor PD-L1 expression: negative | 4.451 (1.062–18.658) | 0.041 |
| Ovarian involvement: bilateral | 1.155 (0.429–3.109) | 0.776 | CD8+ cell density: low | 1.816 (0.462–7.140) | 0.393 |
| CD3+ cell density: low | 1.640 (0.606–4.436) | 0.330 | |||
| CD8+ cell density: low | 3.408 (0.964–12.044) | 0.057 | |||
| FOXP3+ cell density: high | 1.316 (0.490–3.531) | 0.586 | |||
| PD-1+ cell density: high | 0.819 (0.301–2.230) | 0.696 | |||
| Primary tumor size: ≥5 cm | 0.399 (0.134–1.181) | 0.097 | |||
| Lymph node invasion: positive | 1.167 (0.329–4.138) | 0.811 | |||
| Vascular invasion: positive | 0.406 (0.127–1.295) | 0.128 | |||
| Neural invasion: positive | 3.926 (0.507–30.435) | 0.191 | |||
Tumor PD-L1 expression, CD3+ cell density, CD8+ cell density, FOXP3+ cell density, and PD1+ cell density are evaluated in KTs, and variables showing P values less than 0.05 are presented in italic.