Table 1.

List of drugs in this review and their activities

Drug	Species	In vitro form	EC50 (μm)	Selectivity index	Animal study	References
10	L. major	Promastigotes	0·11	–	Y	Diaz-Gonzalez et al. (2011)
	L. donovani	Promastigotes	0·14		N
		Axenic amastigotes	0·07
11	L. major	Promastigotes	0·12	0·08	N	Patel et al. (2014)
		Axenic amastigotes	2·37
12	L. donovani	Intracellular amastigotes	1·08	7·04	Y	Sanderson et al. (2014)
	L. mexicana	Intracellular amastigotes	2·63	2·89	N
13	L. donovani	Intracellular amastigotes	3·73	1·88	Y
	L. amazonensis	Intracellular amastigotes	6·87	1·02	N
	L. mexicana	Intracellular amastigotes	4·72	1·48	N
	L. major	Intracellular amastigotes	3·77	1·86	N
14	L. donovani	Intracellular amastigotes	2·49	2·41	Y
15	L. amazonensis	–	–	–	Y	Wetzel et al. (2012)
16	L. donovani	Axenic amastigotes	0·47	10	N	Wang et al. (2015)
17	L. amazonensis	Promastigotes	13·51	–	Y	Trinconi et al. (2016)
		Intracellular amastigotes	4·25
18	L. amazonensis	Promastigotes	30·2	1·77	Y	Reimao et al. (2014)
		Intracellular amastigotes	16·2
19	L. major	Intracellular amastigotes	>105	–	Y	Berman and Gallalee (1987)
20	L. major	–	–	–	Y	Zakai and Zimmo (2000)
21	L. major	Promastigotes	136	1·82	Y	Shokri et al. (2017)
		Intracellular amastigotes	24
22	L. amazonensis	Promastigotes	0·44	187·5	Y	de Macedo-Silva et al. (2013), Zakai and Zimmo (2000)
		Intracellular amastigotes	0·08
23	L. amazonensis	Promastigotes	2·74	12·2	Y	de Macedo-Silva et al. (2013)
		Intracellular amastigotes	1·63
24	L. infantum	Promastigotes	2–8	3·6	N	Mesquita et al. (2014)
		Intracellular amastigotes	11
25	L. major	Intracellular amastigotes	0·015	>407	N	Khraiwesh et al. (2016)
26			0·061	>100
27			0·091	14·2
28			0·13	>45·4
29	L. infantum	Promastigotes	139	3·09	N	Mesquita et al. (2013)
		Intracellular amastigotes	22
	L. donovani	–	–	–	Y	Zhang et al. (2010)
	L. amazonensis	Promastigote	7·2	115	N	Nava-Zuazo et al. (2014)
30	L. donovani	Promastigotes	5·6	>17·9	Y	Wyllie et al. (2012)
		Axenic amastigotes	2·8
		Intracellular amastigotes	Inactive	–
31	L. amazonensis	–	–	–	Y	Rodrigues et al. (2006)
32	L. amazonensis	–	–	–	Y	Rodrigues et al. (2006)
33	L. donovani	Promastigotes	0·9	>10	Y	Patterson et al. (2013)
		Intracellular amastigotes	4·92
34	L. donovani	Promastigotes	0·16	>54	Y	Patterson et al. (2013)
		Intracellular amastigotes	0·93
35	L. donovani	Promastigotes	0·016	>3125	Y	Patterson et al. (2016)
		Axenic amastigotes	0·005	>10 000
		Intracellular amastigotes	0·087	>575
36	L. donovani	Intracellular amastigotes	Inactive	–	Y	Smith et al. (2000)
37	L. donovani	Promastigotes	Inactive	–	N	Buates and Matlashewski (1999)
		Axenic amastigotes	Inactive	–
		Intracellular amastigotes	Active	–
	L. major	Intracellular amastigotes	21–42	–	Y	El-On et al. (2007)
38	L. infantum	Promastigotes	34	4·14	Y	Pinto et al. (2014)
		Intracellular amastigotes	21
39	L. donovani	Intracellular amastigotes	Active	–	N	Clark et al. (2007)
40	L. mexicana	Promastigotes	1·24	–	N	Navin et al. (2017)
41	L. donovani	Intracellular amastigotes	4·90	–	Y	Chan et al. (1998)
42	L. donovani	Intracellular amastigotes	8·60	0·55	N	Parveen et al. (2005)
43	L. donovani	Promastigotes	>50	9·68	N	De Muylder et al. (2011)
		Axenic amastigotes	>50
		Intracellular amastigotes	3·45
44	L. donovani	Promastigotes	17·30	3·02	N	De Muylder et al. (2011)
		Axenic amastigotes	>50
		Intracellular amastigotes	5·40
45	L. donovani	Promastigotes	37	3·51	N	Singh et al. (2014b)
	L. donovani	Intracellular amastigotes	28
46	L. donovani	Promastigotes	21	2·16	N	Dinesh et al. (2014)
	L. donovani	Intracellular amastigotes	46
47	L. donovani	Promastigotes	23·8	>13	N	Dinesh et al. (2015)
		Intracellular amastigotes	7·5
48	L. mexicana	Promastigotes	0·9	–	Y	Serrano-Martin et al. (2009b)
		Intracellular amastigotes	0·008
49	L. mexicana	Promastigotes	0·115	–	N	Benaim et al. (2014)
		Intracellular amastigotes	0·0007
50	L. major	Promastigotes	0·41	1	N	Firdessa et al. (2015)
		Intracellular amastigotes	4
51	L. donovani	Promastigotes	0·25	–	N	Witschel et al. (2012)