Fig. 3.

A trans-diagnostic approach to obsessive-compulsive disorder (OCD). The predominant symptoms of OCD may result from complex interaction between independent trans-diagnostic dimensions, of which anxiety and compulsivity are good (but not the only) candidates. In this simplified schematic, we show just two putative trans-diagnostic psychiatric dimensions, there are of course many others. The task for basic research, outlined in the Research Domain Criteria initiative is to understand these dimensions at units of analysis, linking self-report symptoms (such as anxiety and compulsivity) to paradigms, physiology, circuits, cells, molecules and genes. GAD, Generalized anxiety disorder.