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. 2018 May 22;86(6):e00090-18. doi: 10.1128/IAI.00090-18

FIG 5.

FIG 5

N. gonorrhoeae wild-type strains outcompete ΔmscS mutant strains in a murine vaginal tract infection model. Bacterial mixtures containing equal amounts of ATCC 49226-catA2 and ATCC 49226-ΔmscS::kanR (study 1), ATCC 49226-kanR and ATCC 49226-ΔmscS::catA2 (study 2), and ATCC 49226-ermC and ATCC 49226-Ng-mscS-C (study 2) were used to inoculate the vaginal tracts of mice. After 24 h, mice were sampled, and growth of the bacteria on agar plates containing selective antibiotics was investigated. The competition index (CI) was calculated as (mutant/wild type)output/(mutant/wild type)input. As a control, in vitro competition indices of liquid cultures were determined after growth for 6 h. Significant differences were identified by analysis of variance (GraphPad Prism). *, P < 0.05; **, P < 0.01.