FIG 3.

(A) Effects of ciprofloxacin and CYS on the microbial load (expressed as log₁₀ CFU per gram of tissue) from the neutropenic mouse thigh model experimentally infected with P. aeruginosa LES431 and treated with vehicle control (lane 1), colistin (5 mg/kg) (lane 2), CYS (1.25 mg/kg) (lane 3), ciprofloxacin (15 mg/kg) (lane 4), and ciprofloxacin plus CYS (lane 5) (n = 5 animals per treatment group). (B) Effects of d.p.i.-administered tobramycin and CYS (expressed as log₁₀ CFU per gram of tissue) in the neutropenic acute lung model of infection with P. aeruginosa ATCC 27853 treated with vehicle only (3 mg mannitol) (lane 1), 3 mg of 5% CYS (lane 2), 3 mg 10% CYS (lane 3), 0.188 mg tobramycin in lactose (4.5 mg total) (lane 4), 5% CYS plus tobramycin (lane 5), and 10% CYS plus tobramycin (lane 6) (n = 8 animals per treatment group). The horizontal lines denote the mean values. One-way ANOVA with Tukey's post hoc analysis (ns, not significant; **, P < 0.01; ***, P < 0.001).