TABLE 1.
CYS and CTM potentiate the antimicrobial activities of ciprofloxacin and reactive oxygen and nitrogen species; MICs of ciprofloxacin, paraquat, H2O2, and SNAP versus P. aeruginosa PAO1
| Drug | MIC (μg/ml) |
|
|---|---|---|
| Alone | In combination | |
| CYS vs. ciprofloxacin | ||
| CYS | 256 | 128 |
| Ciprofloxacin | 0.0625 | 0.0325 |
| CTM vs. ciprofloxacin | ||
| CTM | 1,024 | 256 |
| Ciprofloxacin | 0.0625 | 0.03125 |
| CYS vs. paraquat | ||
| CYS | 256 | <16 |
| Paraquat | >154.3 | 77.1 |
| CTM vs. paraquat | ||
| CTM | 1,024 | 64 |
| Paraquat | >154.3 | 0.3 |
| CYS vs. H2O2 | ||
| CYS | 256 | 256 |
| H2O2 | 2.443 | 1.22 |
| CTM vs. H2O2 | ||
| CTM | 1,024 | <32 |
| H2O2 | 2.443 | 0.305 |
| CYS vs. SNAP | ||
| CYS | 256 | 128 |
| SNAP | >5 | 5 |
| CTM vs. SNAP | ||
| CTM | 1,024 | 64 |
| SNAP | >5 | 0.3125 |