TABLE 2.
Biochemical characterization of isolated antibodies and controlsa
| Antibody | EC50 (nM) |
Tm (°C) | |||
|---|---|---|---|---|---|
| PTx | PTg | PTx S1-220 | PTx B oligomer | ||
| A12 | 0.10 ± 0.03 | 0.18 ± 0.02 | ND | ND | 70.69 ± 0.21 (Tm1), 84.59 ± 0.24 (Tm2) |
| E12 | 0.13 ± 0.006 | 0.05 ± 0.02 | 0.05 ± 0.03 | ND | 74.27 ± 0.08 (Tm1) |
| A8 | 0.15 ± 0.003 | 0.3 ± 0.08 | 0.02 ± 0.006 | ND | 62.06 ± 0.68 (Tm1), 72.29 ± 2.52 (Tm2) |
| D8 | 0.14 ± 0.04 | 0.11 ± 0.08 | ND | 0.78 ± 0.22 | 74.05 ± 1.00 (Tm1) |
| H5 | 0.02 ± 0.01 | 0.06 ± 0.03 | ND | 0.11 ± 0.05 | 70.69 ± 0.74 (Tm1), 89.34 ± 0.70 (Tm2) |
| hu1B7 | 0.06 ± 0.01 | 0.07 ± 0.03b | 0.008 ± 0.002 | ND | ND |
| hu11E6 | 0.17 ± 0.03 | 0.06 ± 0.007b | ND | 1.18 ± 0.19 | ND |
| P-IVIG | 4.26 ± 1.27 | 1.05 ± 0.04 | 9.39 ± 1.67 | ND | ND |
Data are means ± SE. ND, not determined.
A murine antibody was used.