FIG 3.

The combination of adjuvants BcfA and alum elicits better clearance of a B. pertussis infection from the lungs than either adjuvant alone. (A) Mice were immunized with the indicated vaccines and challenged intranasally with Bp536. CFU in the lung were enumerated on days 3 to 21 postinoculation. Each point is the average for 4 or 5 mice per group. One representative experiment of two experiments is shown. *, P ≤ 0.05; **, P ≤ 0.005; ***, P ≤ 0.001. (B) Mice were immunized i.m. on day 0 and boosted on day 28 with 30 μg BcfA/50 μg alum and challenged on day 14 postboost. Lungs were harvested on day 4 postchallenge. NS, not significant.