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. 2018 May 16;9:518. doi: 10.3389/fphar.2018.00518

FIGURE 4.

FIGURE 4

Effects of EGB on the activation of astrocytes and the expression of LCN2, p-JAK2, p-STAT3, in cerebral ischemia rats. (A–C) Double-immunofluorescence staining for astrocytic LCN2, p-STAT3, p-JAK2, and GFAP expression in the ischemic penumbra area after cerebral ischemia. The cells indicated with an arrow were magnified. Scale bar = 20 μm. (D–H) Western blots and quantitative analysis of GFAP, LCN2, p-JAK2, and p-STAT3 expression are expressed as mean ± SEM (n = 4). p < 0.05, ∗∗p < 0.01 and ∗∗∗p < 0.001 vs. sham group; #p < 0.05, ##p < 0.01 and ###p < 0.001 vs. model groups.