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. 2018 May 22;19:157. doi: 10.1186/s12891-018-2077-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Analgesic effect of SI-613 in silver nitrate-induced arthritic pain model in rats. Silver nitrate-induced arthritic rats given 0.05 mg (closed circle), 0.15 mg (closed triangle), 0.5 mg (closed square) SI-613, or vehicle (open circle) intra-articularly, and non-treated normal rats (open square) were evaluated for pain score (a) and weight-bearing rate (b) over time. Mean values of pain scores (c) and weight-bearing rate (d) for 3 days were calculated and subjected to statistical analysis: two-way analyses of variance followed by Williams’ test. ***p < 0.005, **p < 0.01, *p < 0.05 (vs. control, significant level at 5%, two-tailed). Values represent the means ±95% confidence intervals (n = 9 per group, except for the normal group n = 3)