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. 2018 May 22;19:157. doi: 10.1186/s12891-018-2077-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Analgesic effects of SI-613 and its chemical compositions in silver nitrate-induced arthritic pain model in rats. Silver nitrate-induced arthritic rats given SI-613 (closed circle), HA (open triangle), DF-Na + HA (closed triangle), or vehicle (open circle) intra-articularly; those given DF-Na orally once daily for 3 days (open square); and non-treated normal rats (closed square) were evaluated for pain score (a) and weight-bearing rate (b) over time. Mean values of pain scores (c) and weight-bearing rate (d) for 3 days were calculated and subjected to statistical analysis: two-way analyses of variance followed by Tukey’s test. ***p < 0.001 (vs. SI-613, significant level at 5%, two-tailed). Values represent the means ±95% confidence intervals (n = 9 per group, except for the normal group n = 3)