Fig. 6.

Long-lasting anti-inflammatory effect of SI-613 on the knee joint swelling of antigen-induced arthritic rabbits. Two days after the induction of arthritis, 1% SI-613 or PBS was administered at a volume of 500 μL/joint into the joint cavities. The knee joint swelling was evaluated on the day before (day 0), and on days 1, 3, 7, 14, 21, 28, 35, and 42 after the injection of test materials. For statistical analysis, a Student’s t-test with Holm’s correction was used. ***p < 0.001, **p < 0.01, *p < 0.05 (vs. control, significant level at 5%, two-tailed). N.S., not significant. Values represent the means ±95% confidence intervals. (n = 20 per group)