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. 2018 May 22;13:81. doi: 10.1186/s13023-018-0819-1

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Structure of the responder endpoint in rheumatoid arthritis. For the ACR20 endpoint, the continuous ACR-N score is dichotomised at 20% and combined with the rescue medication indicator to form a binary responder index. X1...X8 denotes the disease activity measures which are combined to form the continuous ACR-N score