Table 3.
Association between CRP, SAA, sTNFRII, and CXCL9/MIG and lung cancer risk, stratified by time from blood collection to lung cancer diagnosis using data from both the discovery and replication studies
| <2 y (257 case patients, 299 control subjects) |
2–4 y (468 case patients, 397 control subjects) |
4–6 y (198 case patients, 180 control subjects) |
6+ y (252 case patients, 219 control subjects) |
||
|---|---|---|---|---|---|
| Marker | Category | ORs (95% CIs)* | ORs (95% CIs)* | ORs (95% CIs)* | ORs (95% CIs)* |
| CRP | 1 | 1.0 | 1.0 | 1.0 | 1.0 |
| 2 | 1.18 (0.67 to 2.08) | 1.12 (0.71 to 1.76) | 1.37 (0.69 to 2.70) | 1.46 (0.77 to 2.79) | |
| 3 | 1.33 (0.76 to 2.33) | 1.42 (0.92 to 2.19) | 1.11 (0.56 to 2.19) | 1.61 (0.86 to 3.04) | |
| 4 | 2.20 (1.23 to 3.95) | 1.77 (1.16 to 2.70) | 2.26 (1.17 to 4.36) | 2.25 (1.17 to 4.33) | |
| Ptrend† | .005 | .003 | .03 | .02 | |
| Pinteraction = .34 | |||||
| SAA | 1 | 1.0 | 1.0 | 1.0 | 1.0 |
| 2 | 1.47 (0.83 to 2.57) | 1.54 (1.00 to 2.39) | 1.92 (0.97 to 3.81) | 1.58 (0.88 to 2.83) | |
| 3 | 1.87 (1.06 to 3.30) | 1.40 (0.92 to 2.13) | 3.29 (1.49 to 7.26) | 1.84 (1.02 to 3.33) | |
| 4 | 2.29 (1.32 to 3.99) | 1.54 (0.99 to 2.38) | 3.34 (1.60 to 6.98) | 3.00 (1.53 to 5.87) | |
| Ptrend† | .003 | .09 | <.001 | .002 | |
| Pinteraction = .99 | |||||
| sTNFRII | 1 | 1.0 | 1.0 | 1.0 | 1.0 |
| 2 | 2.33 (1.36 to 3.98) | 1.26 (0.82 to 1.93) | 1.28 (0.67 to 2.47) | 0.71 (0.41 to 1.25) | |
| 3 | 2.26 (1.29 to 3.96) | 1.19 (0.78 to 1.82) | 1.60 (0.78 to 3.26) | 0.90 (0.49 to 1.63) | |
| 4 | 2.00 (1.13 to 3.53) | 1.68 (1.11 to 2.56) | 1.62 (0.83 to 3.16) | 1.24 (0.65 to 2.37) | |
| Ptrend† | .02 | .03 | .15 | .43 | |
| Pinteraction = .26 | |||||
| CXCL9/MIG | 1 | 1.0 | 1.0 | 1.0 | 1.0 |
| 2 | 1.75 (1.01 to 3.06) | 0.72 (0.46 to 1.12) | 0.93 (0.47 to 1.84) | 1.09 (0.60 to 1.99) | |
| 3 | 3.07 (1.69 to 5.58) | 0.98 (0.63 to 1.51) | 0.99 (0.52 to 1.88) | 1.54 (0.84 to 2.83) | |
| 4 | 2.46 (1.41 to 4.32) | 1.39 (0.89 to 2.16) | 1.80 (0.95 to 3.39) | 2.08 (1.12 to 3.85) | |
| Ptrend† | <.001 | .05 | .06 | .01 | |
| Pinteraction = .63 |
* Odds ratios and 95% confidence intervals were estimated in conditional logistic regression models. Models were adjusted for matching criteria, personal history of bronchitis/emphysema, history of coronary heart disease or heart attack, family history of lung cancer, use of aspirin/ibuprofen, body mass index, race, and education. CI = confidence interval; CXCL9/MIG = monokine induced by gamma interferon; CRP = C-reactive protein; OR = odds ratio; SAA = serum amyloid A; sTNFRII = soluble tumor necrosis factor receptor-2.
† Two-sided Ptrend values across marker categories were assessed with the Wald test using marker levels as an ordinal variable with 1 degree of freedom.