Table 4.

Modulation of HO-1 in different disease experimental models.

Species and Strain	Cell line	HO-1 inducer	HO-1 inhibitor	HO-1 localization	Effect	References
Human	Isolated monocytes	Hemin	ZnPPIX	Monocytes	More HO-1 leads to less apoptosis in monocytes	Lang et al., 2005
Human	Isolated neutrophils	Hemin	SnPP	Neutrophils	More HO-1 associated with severe malaria	Walther et al., 2012
Kunming mouse	–	Artesunate	ZnPPIX	Lungs	More HO-1 leads to ALI induced by CLP	Cao et al., 2016
Mouse C57BL/6	–	A toxin (enteritis)	SnPP	F4/80 macrophages	More HO-1 leads to more CX3CR1 and less enteritis	Inui et al., 2011
Mouse Balb/c	Isolated peritoneal cells	Hemin	–	Peritoneal and pancreatic macrophages	More HO-1 leads to less acute pancreatitis and ALI	Nakamichi et al., 2005
Mouse C57BL/6	CRL-2581 - murine endothelial cells	Heme and COPPIX	ZnPPIX	Kidneys, brain and lungs	P. berghei infection leads to more HO-1 in ECM	Liu et al., 2012
Mouse C57BL/6	–	Hemin	ZnPPIX	Lungs	More HO-1 leads to less ALI/ARDS induced by sepsis	Luo et al., 2014
Mouse C57BL/6	HUVECs and MECs	CoPPIX	ZnPPIX	HUVECs and MECs	More HO-1 leads to less complement mediated vascular endothelium injury	Kinderlerer et al., 2009
Mouse Balb/c	RAW 264.7 cells	CoPPIX	ZnPPIX	–	More HO-1 leads to less ALI induced by LPS	Yin et al., 2011
New Zealand white rabbit	–	Hemin	–	Neutrophils, macrophages and lung alveolar epithelial cells	More HO-1 leads to less ALI/ARDS induced by ventilation	An et al., 2011
Rat	Alveolar macrophages	Hemin	ZnPPIX	Alveolar macrophages	More HO-1 leads to more anti-inflammatory responses	Chen et al., 2012
Rat	Rat alveolar macrophage cells	Hemin	ZnPPIX	Lungs; alveolar macrophages	Lung oxidative stress injury reduced with HO-1 induction	Yu et al., 2016
Sprague Dawley rat	–	Hemin	–	Lungs	More HO-1 leads to less ALI induced by explosion	Chavko et al., 2008
Sprague Dawley rat	A549 cells	–	ZnPPIX	Lungs	More HO-1 leads to ALI induced by I/R	Wu et al., 2013