Table 1. List of the top differentially expressed miRNAs between diseased and healthy gingival tissues (P<0.01).
| miRNAs | Mature sequence | Fold-change | Regulation |
|---|---|---|---|
| (A) Top eight miRNAs with increased expression in diseased compared with healthy gingiva | |||
| cfa-miR-452 | AACUGUUUGCAGAGGAAACUGA | 2.52 | Up |
| cfa-miR-375 | UUUGUUCGUUCGGCUCGCGUGA | 2.43 | Up |
| cfa-miR-98 | UGAGGUAGUAAGUUGUAUUGUU | 2.38 | Up |
| cfa-miR-145 | GUCCAGUUUUCCCAGGAAUCCCU | 1.96 | Up |
| cfa-let-7e | UGAGGUAGGAGGUUGUAUAGUU | 1.71 | Up |
| cfa-miR-142 | CCCAUAAAGUAGAAAGCACUA | 1.71 | Up |
| cfa-miR-500 | AUGCACCUGGGCAAGGAUUCU | 1.70 | Up |
| cfa-miR-7 | UGGAAGACUAGUGAUUUUGUUGU | 1.68 | Up |
| (B) Top 30 miRNAs with decreased expression in diseased compared with healthy gingiva | |||
| cfa-let-7g | UGAGGUAGUAGUUUGUACAGUU | −1.51 | Down |
| cfa-miR-486 | UCCUGUACUGAGCUGCCCCGA | −1.51 | Down |
| cfa-miR-152 | UCAGUGCAUGACAGAACUUGG | −1.51 | Down |
| cfa-miR-127 | UCGGAUCCGUCUGAGCUUGGCU | −1.55 | Down |
| cfa-miR-1271 | CUUGGCACCUAGUAAGCACU | −1.56 | Down |
| cfa-miR-101 | UACAGUACUGUGAUAACUGA | −1.57 | Down |
| cfa-miR-16 | UAGCAGCACGUAAAUAUUGGCG | −1.61 | Down |
| cfa-miR-200a | CAUCUUACCGGACAGUGCUGGA | −1.61 | Down |
| cfa-miR-140 | ACCACAGGGUAGAACCACGGA | −1.67 | Down |
| cfa-miR-27b | UUCACAGUGGCUAAGUUCUGC | −1.69 | Down |
| cfa-miR-146a | UGAGAACUGAAUUCCAUGGGUU | −1.74 | Down |
| cfa-miR-204 | UUCCCUUUGUCAUCCUAUGCCU | −1.80 | Down |
| cfa-miR-29a | UAGCACCAUCUGAAAUCGGUUA | −1.81 | Down |
| cfa-miR-26a | UUCAAGUAAUCCAGGAUAGGCU | −1.83 | Down |
| cfa-miR-451 | AAACCGUUACCAUUACUGAGUU | −1.89 | Down |
| cfa-miR-125a | UCCCUGAGACCCUUUAACCUGU | −1.92 | Down |
| cfa-miR-93 | CAAAGUGCUGUUCGUGCAGGUAG | −1.96 | Down |
| cfa-miR-361 | UUAUCAGAAUCUCCAGGGGUAC | −1.97 | Down |
| cfa-miR-27a | UUCACAGUGGCUAAGUUCCG | −2.03 | Down |
| cfa-miR-532 | CAUGCCUUGAGUGUAGGACCGU | −2.09 | Down |
| cfa-let-7c | UGAGGUAGUAGGUUGUAUGGUU | −2.11 | Down |
| cfa-miR-23a | AUCACAUUGCCAGGGAUUU | −2.33 | Down |
| cfa-miR-211 | UUCCCUUUGUCAUCCUUUGCCU | −2.35 | Down |
| cfa-miR-92b | UAUUGCACUCGUCCCGGCCUCC | −2.40 | Down |
| cfa-miR-342 | UCUCACACAGAAAUCGCACCCGU | −2.58 | Down |
| cfa-miR-340 | UUAUAAAGCAAUGAGACUGAUU | −3.04 | Down |
| cfa-miR-374a | UUAUAAUACAACCUGAUAAGU | −3.09 | Down |
| cfa-miR-9 | UCUUUGGUUAUCUAGCUGUAUGA | −4.22 | Down |
| cfa-miR-429 | UAAUACUGUCUGGUAAUGCCGU | −5.58 | Down |
| cfa-miR-20a | UAAAGUGCUUAUAGUGCAGGUAG | −7.52 | Down |