Table 2.
The association between PD-L1 expression, CD8+ T cell infiltration and clinicopathologic parameters in PNETs
| Variable | PD-L1 expression | CD8+ T cell density in stroma | NA | |||||
|---|---|---|---|---|---|---|---|---|
| N(%) | Positive | Negative | p | ≤264.6/mm2 | >264.6/mm2 | p | ||
| Total | 159 (100.0) | 72 (45.3) | 87 (54.7) | 80 (50.3) | 79 (49.7) | |||
| Age | 0.241 | 0.578 | ||||||
| ≤ 59.5 | 78 (49.1) | 39 (54.2) | 39 (44.8) | 41 (51.3) | 37 (46.8) | |||
| >59.5 | 81 (50.9) | 33 (45.8) | 48 (55.2) | 39 (48.7) | 42 (53.2) | |||
| Gender | 0.365 | 0.189 | ||||||
| Male | 109 (68.6) | 52 (72.2) | 57 (65.5) | 51 (63.8) | 58 (73.4) | |||
| Female | 50 (31.4) | 20 (27.8) | 30 (34.5) | 29 (36.3) | 21 (26.6) | |||
| Necrosis | < 0.001* | 0.096 | ||||||
| No | 85 (53.5) | 17 (23.6) | 68 (78.2) | 48 (60.0) | 37 (46.8) | |||
| Yes | 74 (46.5) | 55 (76.4) | 19 (21.8) | 32 (40.0) | 42 (53.2) | |||
| Vascular invasion | 0.072 | 0.004* | ||||||
| No | 129 (81.1) | 54 (75.0) | 75 (86.2) | 72 (90.0) | 57 (72.2) | |||
| Yes | 30 (18.9) | 18 (25.0) | 12 (13.8) | 8 (10.0) | 22 (27.8) | |||
| Preoperative therapy | 0.538 | 0.113 | ||||||
| No | 148 (93.1) | 68 (94.4) | 80 (92.0) | 77 (96.3) | 71 (89.8) | |||
| Yes | 11 (6.9) | 4 (5.6) | 7 (8.0) | 3(3.7) | 8 (10.2) | |||
| Tumor type | < 0.001* | 0.005* | ||||||
| SCLC | 94 (59.1) | 48 (51.1) | 46 (48.9) | 50 (53.2) | 44 (46.8) | |||
| LCNEC | 28 (17.6) | 21 (75.0) | 7 (25.0) | 7 (25.0) | 21 (75.0) | |||
| TC | 35 (22.0) | 3 (8.6) | 32 (91.4) | 23 (65.7) | 12 (34.3) | |||
| AC | 2 (1.3) | 0 (0.0) | 2 (100.0) | 0 (0.0) | 2 (100.0) | |||
| Pathological grading | < 0.001* | 0.100 | ||||||
| High | 122 (76.7) | 69 (95.8) | 53 (60.9) | 57 (71.2) | 65 (82.3) | |||
| Low | 37 (23.3) | 3 (4.2) | 34 (39.1) | 23 (28.8) | 14 (17.7) | |||
| Lymph node metastasis | 0.170 | 0.005* | 13 (8.2) | |||||
| No | 83 (56.8) | 34 (50.7) | 49 (62.8) | 33 (45.2) | 50 (68.5) | |||
| Yes | 63 (43.2) | 33 (49.3) | 30 (37.2) | 40 (54.8) | 23 (31.5) | |||
| Clinical Staging | 0.314 | 0.007* | 15 (9.4) | |||||
| I | 70 (48.6) | 29 (41.4) | 41 (58.6) | 27 (38.6) | 43 (61.4) | |||
| II | 27 (18.8) | 10 (37.0) | 17 (63.0) | 14 (51.9) | 13 (48.1) | |||
| III | 47 (32.6) | 25 (53.2) | 22 (46.8) | 32 68.1) | 15 (31.9) | |||
Abbreviation: NA not available
*stands for the value of p < 0.05