TABLE 2.
SELECTION OF GENES CONSISTENTLY DOWNREGULATED GREATER THAN FOURFOLD IN MOUSE LIVER TREATED WITH Wy-14, 643 FOR 2 WEEKS
| Genebank Acc. | Fold Change | Gene Description | Chrom. Mapping | Putative Function |
|---|---|---|---|---|
| AA546085 | −19.1 | antigen-containing epitope to antibody MMS-85/12 | — | unknown |
| AA546673 | −17.0 | MutS homolog 2 (E. coli) | 17 | cell cycle, DNA repair |
| AA387579 | −16.2 | pannexin 1 | — | cell–cell interaction |
| AI509029 | −16.2 | sine oculis-related homeobox 3 homolog | 17 | development |
| AA260001 | −14.7 | Wee 1 homolog (S. pombe) | — | cell cycle |
| AA277571 | −14.0 | polymeric immunoglobin receptor | 1 | apoptosis |
| AA-023077 | −14.0 | hydroxysteroid 11-β dehydrogenase 1 | — | steroid metabolism |
| AA517145 | −13.0 | L-threonine 3-dehydrogenase mRNA | — | metabolism |
| AA207872 | −12.8 | renin 1 | 1 | blood pressure control |
| AA538499 | −12.6 | phosphatidylinositol-4-phosphate 5-kinase, type II, α | — | signal transduction |
| AA268683 | −12.1 | kinesin-associated protein 3 | — | cytoskeletal |
| AA517717 | −11.6 | ankyrin repeat hooked to zinc finger motif | — | transcription |
| AA253725 | −11.4 | neurofilament-L | 14 | cytoskeletal |
| AA432951 | −11.3 | myoblastosis oncogene-like 2 | 2 | cell cycle |
| AA009039 | −10.6 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase | 11 | metabolism |
| AA387076 | −10.6 | testis-specific gene A 12 | 10 | unknown |
| AA426866 | −9.8 | serine/threonine kinase 18 | 13 | signal transduction |
| AA030546 | −9.6 | insulin-like growth factor 2 | 7 | cell growth |
| W45834 | −9.5 | proteoglycan 3 | 2 | extracellular matrix |
| AA020100 | −9.5 | tissue factor pathway inhibitor | — | blood coagulation |
| AA426845 | −8.5 | SRY-box containing gene 15 | 11 | testis determination factor |
| AI327515 | −8.4 | excision repair 1 | 7 | transcription/replication |
| AA422377 | −8.4 | growth differentiation factor 9 | 11 | cell growth |
| AA545607 | −8.4 | metal response element binding transcription factor 2 | — | transcription |
| AA162875 | −7.5 | CD53 antigen | 3 | apoptosis |
| AA270669 | −7.3 | laminin, alpha 4 | 10 | cytoskeletal |
| AA387258 | −7.2 | myosin IB | 1 | cytoskeletal |
| AA542013 | −6.8 | fibroblast growth factor receptor 1 | 8 | cell growth |
| AA473938 | −6.7 | CCAAT/enhancer binding protein alpha (C/EBP) | 17 | transcription |
| AA414632 | −6.7 | cyclin-dependent kinase like 2 | 5 | cell cycle |
| W55655 | −6.6 | myeloperoxidase | 11 | inflammation |
| W83974 | −6.3 | carboxypeptidase E | 8 | metabolism |
| AA285921 | −5.5 | major urinary protein 2 | — | pheromone |
| W89253 | −4.9 | insulin-like growth factor binding protein 5 | 1 | cell growth |
| AA274685 | −4.6 | hydroxysteroid dehydrogenase Δ5,3-β | 3 | steroid metabolism |
| AI326579 | −4.0 | nuclear receptor coactivator 1 | 12 | transcription |
Mouse chromosome location of the gene, Genebank accession number, and putative function are indicated. —: not known.