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Left: model of the nine-zinc finger protein TFIIIA with the 5S RNA gene internal control region (ICR). Middle: sequence of the ICR recognized by zinc finger 4 in the minor groove. Right: complex of a polyamide with its target site, 5′-AGTACT-3′. Circles with dots represent the lone pairs of N(3) of purines and O(2) of pyrimidines, and circles containing an H represent the 2-amino group of guanine. Hydrogen bonds are shown as dashed lines.
