Table 1. Overview of transmembrane anion transport data: EC₅₀, n, initial rate of chloride release (k_ini), log P and retention times ^a .

Compound		EC50 b	Hill parameter n	k ini c	log P d	Retention time (min)
1		0.00719	1.19	0.952	3.08	10.4
2		0.00613	1.23	1.41	3.74	11
3		0.00699	1.25	1.24	4.17	11.6
4		0.00779	1.32	1.17	4.63	12.2
5		0.0104	1.29	1.02	4.72	11.9
6		0.00951	1.25	1.13	5.02	12.7
7		0.288	0.965	0.0231	7.11	14.5
8		0.0688	1.42	0.229	2.58	8.8
9		0.0197	1.29	0.638	2.86	9.8
10		0.0134	1.28	0.786	3.37	10.5
11		0.0231	1.31	0.470	3.76	11
12		0.0260	1.29	0.494	3.2	10.4
13		0.0208	1.18	0.474	2.92	9.6
14		0.0155	1.27	0.661	3.49	10.3
15		0.0236	1.37	0.444	3.62	10.5
16		0.0221	1.29	0.510	3.76	10.8
17		0.0167	1.48	0.830	2.68	9
18		0.0494	1.59	0.314	2.11	8.2
19		0.197	0.853	0.0919	1.88	n.d.
20		0.346	1.30	0.0368	1.03	7
21		0.0921	1.08	0.215	1.55	7.7
22		0.0274	1.03	0.517	2.03	8.5
23		0.0116	0.860	0.743	2.46	9.3
24		0.00648	1.18	1.46	2.99	10.2
25		0.005	1.19	1.50	3.52	10.9
26		0.00451	1.51	1.52	4.02	11.5
27		0.00312	1.07	2.63	4.79	12.1
28		0.0038	1.10	1.63	5.1	12.6
29		0.0053	1.33	1.54	5.36	13.1
30		0.00731	1.15	1.09	6.14	13.8
31		0.0113	1.20	0.941	2.24	9.2
32		0.00668	1.05	1.01	2.84	10
33		0.0977	0.963	0.224	1.5	n.d.
34		0.0157	1.32	0.744	4.4	11.5
35		0.0116	1.20	0.708	5.94	13.1
36		0.0123	0.857	0.321	6.46	n.d.
37		0.0133	1.45	0.600	4.38	11.6
38		0.00878	1.43	1.69	3.3	11.3
39		0.0196	1.14	0.605	3.62	10.7
40		0.00968	1.74	1.16	4.49	11.9
41		0.00517	1.15	1.04	6.07	n.d.
42		0.0204	0.929	0.420	6.42	13.9
43		0.0616 e	— e	0.186	7.14	10.4

^an.d. not determined.

^bmolar percentage with respect to POPC, mol%.

^cValues calculated by fitting the plot of relative chloride release (y) versus time (x) for 0.05 mol% compound to lipid to an asymptotic function y = a – b × c^x. The initial rate of chloride release (k_ini in % s^–1) is given by –b ln(c).

^dLog P values calculated using ALOGPs 2.1 software.

^eDetermined via correlation between k_ini and EC₅₀ (see ESI).