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Cancer Associated Fibroblasts (CAFs) promote BCa cells growth and resistance to tamoxifen through FGFR2. A) T47D cells were grown for 14 days in 3D matrigel in the presence of CAFs-conditioned medium with/without FGFR inhibitor (PD173074, 100 nM), B-D) FGFR2 involvement in CAFs-mediated cell growth and resistance to tamoxifen was evaluated. Scale represents 100 μm, *P ≤ .05, **P ≤ .001, n = 3.
1Ratios to control/non-treated cells.
