Figure 5.
Behavior and neurochemical analysis of mitoNEET knockout mice. (A) The stride length of mice was decreased significantly following the deletion of mitoNEET. (B) Transgenic mice were less able to maintain balance on the rotarod and fell from the rod quicker than wild-type control animals. (C) HPLC analysis of striatal homogenates revealed a significant decrease in levels of dopamine at six months following deletion of mitoNEET. Data are mean ± SEM where N = 5–7 mice. *Statistical significance P < 0.05. Abbreviations are wild-type (WT); mitoNEET knockout (KO).