Table 1.

Ranking of candidate proteins from (A) calcium signaling pathway and (B) ECM–receptor interaction pathway by random walk node weights (RWNW) using PPI data from three databases.

APID			Reactome			Mentha
Gene	RWNW	Edges	Gene	RWNW	Edges	Gene	RWNW	Edges
(A) Calcium signaling pathway
PRKCA	0.062	10	GNA14	0.046	14	EGFR	0.079	13
EGFR	0.054	8	CALML3	0.030	12	RYR2	0.061	6
RYR2	0.049	4	PRKCA	0.029	10	PRKCA	0.057	5
GNAQ	0.045	3	RYR2	0.028	12	PLCB1	0.056	5
RYR1	0.045	3	RYR3	0.027	11	GRIN1	0.053	4
GRIN1	0.044	5	RYR1	0.027	11	RYR1	0.052	4
ITPR1	0.041	3	PRKCB	0.027	14	PTGER3	0.050	3
PLCB1	0.039	3	GNAQ	0.024	8	SYK	0.047	3
SYK	0.038	5	EGFR	0.024	8	ERBB4	0.044	2
PRKCB	0.035	4	PLCB1	0.023	11	ATP2B4	0.044	2
(B) ECM–receptor interaction pathway
FN1	0.137	8	FN1	0.0486	21	FN1	0.1227	5
DAG1	0.088	3	LAMA1	0.0470	19	DAG1	0.1077	4
LAMA1	0.081	3	ITGB3	0.0446	18	LAMA1	0.0885	3
CD36	0.069	3	ITGA1	0.0445	20	SDC2	0.0810	2
SDC2	0.069	2	LAMC3	0.0444	19	ITGB3	0.0810	2
HSPG2	0.060	2	LAMA3	0.0440	18	HSPG2	0.0781	3
ITGB3	0.059	2	LAMA5	0.0428	17	LAMA3	0.0660	1
COL4A2	0.059	2	COL4A2	0.0414	17	CD36	0.0660	1
LAMA3	0.057	1	ITGA4	0.0412	18	ITGA1	0.0627	1
AGRN	0.055	1	ITGA9	0.0412	18	AGRN	0.0619	1

Candidate genes in bold were identified in every interactome.