Table 3.

Pharmacologic profile of endothelial cell-inhibitory activity in diabetes autoantibodies

Antagonist [Conc]	GPCR	% Neutralization of Diab Autoantibody-induced EC cell death
M100907 [2 µM]	5-HT2a/b/c	100%
M100907 [200 nM]	5-HT2a/b/c	80%
M100907 [100 nM]	5-HT2a/b/c	22%
Ketanserin [100 nM]	5-HT2a/c	0%
Prazosin [1µM]	A1-AR	0%
Losartan [10µM]	A1-1R	23%
Bosentan [10 µM]	ET-AR	17%
CTEP [10 µM]	mGlu-5R	15%

A1-AR- alpha 1 adrenergic receptor; AT-1R- angiotensin II, type 1 receptor; ET-AR- endothelin A receptor, mGlu-5R- metabotropic glutamate 5 receptor