Table 1.
1 | Poor access to rigorously annotated, fit-for-purpose biospecimens from stringently phenotyped sources |
2 | Insufficient control of pre-analytical parameters |
3 | Low reproducibility of academic publications |
4 | Incomplete understanding of physiology |
5 | Variable analytical standards |
6 | Idiosyncratic laboratory-specific analytical methods |
7 | Small studies lacking statistical power |
8 | Chaotic data reporting formats and poor database interoperability |
9 | Poor compliance on reporting standards by scientific journals |
10 | Poor to non-existent quality management systems |