Table 6.

Mediation analysis indicating average causal mediation effect of sleep efficiency on relationship between exposure to maltreatment (number of different types) and regional grey matter volume

	Average Causal Mediation Effect		Average Direct Effect		Total Effect		Proportion Mediated
Regions	Estimate	p-value	Estimate	p-value	Estimate	p-value	Estimate	p-value
Hippocampus	−61.92	.043	−68.43	.222	−130.35	.004	0.463	.047
CA1	−10.83	.032	−17.18	.063	−28.01	.003	0.385	.035
Dentate gyrus	−5.49	.022	−7.45	.105	−12.94	.002	0.411	.024
Molecular layer	−10.35	.008	−12.63	.104	−22.98	.002	0.444	.01
Inferior Frontal Cortex	−140.84	.054	−162.82	.171	−303.66	<.0005	0.455	.054
Insula	−80.97	.459	−194.55	.214	−275.52	.002	0.299	.461

The Average Causal Mediation Effect indicates the degree of reduction in grey matter volume attributed to the mediator.