Figure 1.
The quinoline-3-carboxamide laquinimod does not inhibit neutrophil degranulation induced by S100A9 or fMLP. Human neutrophils were preincubated for 30 minutes with increasing concentrations of laquinimod (Laq) or with its diluent (dimethyl sulfoxide [DMSO]) and then stimulated for 30 minutes with 10 µg/mL of S100A9 or 10−7 M fMLP. The cells were then stained with anti CD35 (A) or anti CD66b (B) and analyzed by flow cytometry. Data shown are the mean fluorescence intensity (± standard error of the mean [SEM]) measured in 3 experiments performed on cells from different donors. MFI, mean fluorescence intensity.