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. 2018 Mar 7;57(6):1105–1114. doi: 10.1093/rheumatology/kex525

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Published by Oxford University Press on behalf of the British Society for Rheumatology 2018. This work is written by US Government employees and is in the public domain in the US.

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Fig. 2 — MR1 promotes trabecular bone accretion in lumbar vertebrae of skeletally mature mice

Mice were administered Ig (control) or MR1 for 6 months, beginning at 5 months of age and L3 lumbar vertebrae analysed by micro-CT (μCT). (A) Representative μCT reconstructions of trabecular bone. Four representative images are shown for each group. The white scale bar = 500 µm. Quantitative microarchitectural indices of vertebral bone volume and structure were further determined. (B) Tissue volume (TV), (C) bone volume (BV), (D) BV/TV, (E) Tb. N, (F) Tb.Th, (G) Tb.Sp, (H) TV.D and (I) SMI. Cortical indices: (J) Ct.Th, (K) cortical bone area (Ct.Ar), (L) total cross-sectional area (Tt.Ar) and (M) Ct.Ar/Tt.Ar. *P < 0.05; **P < 0.01; by Mann–Whitney test. n = 7 Ig and 7 MR1 mice/group. Mean (s.d.). BV/TV: bone volume fraction; Ct.Th: average cortical thickness; Ct.Ar/Tt.Ar: cortical area fraction; SMI: structure model index; Tb.N: trabecular number; Tb.Th: trabecular thickness; Tb.Sp: trabecular separation; TV.D: trabecular volumetric bone density.