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. 2018 Mar 7;57(6):1105–1114. doi: 10.1093/rheumatology/kex525

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Published by Oxford University Press on behalf of the British Society for Rheumatology 2018. This work is written by US Government employees and is in the public domain in the US.

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Fig. 3 — Biochemical markers of bone formation and quantitative bone histomorphometry in Ig- and MR1-treated mice

Markers of bone turnover were quantified in serum after administration of MR1 or Ig for 2 months. (A) C-terminal telopeptide of collagen type I, a sensitive and specific marker of bone resorption. (B) Osteocalcin, a sensitive and specific marker of bone formation. ***P < 0.001, by Student’s t-test, n = 10 mice/group. (C) Representative images of double calcein labelled vertebral trabecular bone sections from mice treated for 6 months with MR1 or Ig control. White line = 100 micrometers.