Table 1.
Bone histomorphometry of vertebrae treated with MR1 or Ig for 6 months
| Index | Ig | MR1 | % Change | P-value |
|---|---|---|---|---|
| BV/TV, mean (s.d.), % | 0.0861 (0.0278) | 0.1777 (0.0532) | +106.3 | 0.0017 |
| MS/BS, mean (s.d.), % | 0.2833 (0.0819) | 0.3902 (0.0528) | +37.7 | 0.0133 |
| MAR, mean (s.d.), µm/day | 1.0742 (0.2195) | 0.9623 (0.1230) | −10.4 | 0.2617 |
| BFR/BS, mean (s.d.), µm/day | 0.3163 (0.0931) | 0.3795 (0.0924) | +20.0 | 0.2990 |
| N.Ob/BS, mean (s.d.), mm | 4.67 (2.49) | 14.29 (2.69) | +205.7 | <0.0001 |
| Ob.S/BS, mean (s.d.), % | 8.55 (8.50) | 25.82 (6.52) | +201.7 | <0.0001 |
All values listed as mean (s.d.). N = 7 samples/group. P-value: actual P-values by Student’s t-test; BS: bone surface; BV/TV: bone volume fraction; MS: mineralizing surface; MAR: mineral apposition rate; BFR: bone formation rate; Ob.S: osteoblast surface; N.Ob: number of osteoblasts.