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. Author manuscript; available in PMC: 2018 May 23.
Published in final edited form as: Compr Physiol. 2015 Dec 15;6(1):423–441. doi: 10.1002/cphy.c150009

Figure 4.

Figure 4

Diagram depicting renal proximal tubule, TALH, and CCD cell signaling for EETs and 20-HETE. Proximal tubule cell: 20-HETE inhibits basolateral Na-K ATPase activity to decrease sodium reabsorption. EETs inhibit basolateral Na-K ATPase activity and apical NHE3 to decrease sodium reabsorption. TALH: 20-HETE inhibits apical K+ channels to limit K+ availability for transport via the Na-K-2Cl− transporter resulting in decreased lumen positive transepithelial potential and passive reabsorption of cations. CCD: EETs inhibit apical ENaC and basolateral K+ channels to decrease sodium reabsorption.