Table 1.
Genes Differentially Expressed in Lactating Mammary Glands of Plg-RKT−/− Mice and Plg-RKT−++ Mice
| Gene Symbol | Description | Fold Regulation | P Value |
|---|---|---|---|
| Ctgf | Connective tissue growth factor | 9.5461 | 0.000306 |
| Edn1 | Endothelin 1 | 4.7346 | 0.00814 |
| Grem1 | Gremlin 1 | 3.5022 | 0.040351 |
| Hgf | Hepatocyte growth factor | 6.1685 | 0.031379 |
| Il1a | Interleukin 1 alpha | 9.7242 | 0.025592 |
| Il4 | Interleukin 4 | 3.7884 | 0.029965 |
| Itga2 | Integrin alpha 2 | 15.7061 | 0.007263 |
| Itgb1 | Integrin beta 1 (fibronectin receptor beta) | 2.4004 | 0.026171 |
| Itgb3 | Integrin beta 3 | 10.0788 | 0.018231 |
| Itgb6 | Integrin beta 6 | 3.9084 | 0.009638 |
| Itgb8 | Integrin beta 8 | 11.1573 | 0.015793 |
| Ltbp1 | Latent transforming growth factor beta binding protein 1 | 16.3164 | 0.004637 |
| Mmp2 | Matrix metallopeptidase 2 | 5.1512 | 0.02475 |
| Mmp9 | Matrix metallopeptidase 9 | 3.1057 | 0.027788 |
| Pdgfb | Platelet derived growth factor, B polypeptide | 2.5255 | 0.045256 |
| Serpine1 | Serine (or cysteine) peptidase inhibitor, clade E, member 1 | 3.2676 | 0.046089 |
| Smad2 | MAD homolog 2 (Drosophila) | 2.2474 | 0.03523 |
| Tgfb3 | Transforming growth factor, beta 3 | 8.3682 | 0.006022 |
| Tgfbr1 | Transforming growth factor, beta receptor I | 2.5726 | 0.044485 |
| Timp2 | Tissue inhibitor of metalloproteinase 2 | 6.5052 | 0.02108 |
| Tnf | Tumor necrosis factor | 5.2111 | 0.017668 |
| Akt1 | Thymoma viral proto-oncogene 1 | −2.7993 | 0.00061 |
| Egf | Epidermal growth factor | −12.2957 | 0.000286 |
| Mmp1a | Matrix metallopeptidase 1a (interstitial collagenase) | −3.7496 | 0.002683 |
| Timp4 | Tissue inhibitor of metalloproteinase 4 | −2.4511 | 0.013536 |
Regulated genes with Ct threshold < 35, P value <0.05 and > 2-fold change differences, n=3 per group