Table 3. Studies Reporting Significant Haplotype Associations by Gene.
For each association the genetic variants composing the haplotype, the study population, and the reference are reported. Inclusion criteria for a particular gene to be located in this table included at least 5 studies reporting genetic variation within that gene In the situation genetic variants composing a haplotype were located within multiple genes, such as the HLA region, the haplotype association was only reported for one gene.
| Gene | Haplotype | Population | Reference |
|---|---|---|---|
| HLA-A | |||
|
| |||
| HLA-A2-DRB1*1502 | Indian | [100] | |
|
|
|||
| HLA-A*24-B*40-DRB1*15 | Indian (Sahariya) | [93] | |
|
|
|||
| HLA-A*02-B*40-DRB1*16 | Indian (Sahariya) | [93] | |
|
|
|||
| HLA-A*02-B*40-DRB1*03 | Indian (Sahariya) | [93] | |
|
| |||
| HLA-DQB1 | |||
|
| |||
| HLA-DQB1*301-304 | South African | [103] | |
|
|
|||
| HLA-DQB1*0601-DPB1*0201 | Indian | [98] | |
|
| |||
| HLA-DRB1 | |||
|
| |||
| HLA-DRB1*1101-1121-DQB1*05 | South African | [103] | |
|
|
|||
| HLA-DRB1*16-DQB1*05 | Polish | [96] | |
|
|
|||
| HLA-DRB1*04-DQB1*03 | Polish | [96] | |
|
|
|||
| HLA-DRB1*1601-DQB1*0502 | Polish | [96] | |
|
|
|||
| HLA-DRB1*11-DQB1*03 | Polish | [96] | |
|
|
|||
| HLA-DRB1*1502-DQB1*0601-DPB1*201 | Indian | [98] | |
|
|
|||
| HLA-B40-DRB1*1501 | Indian | [100] | |
|
|
|||
| HLA-B40-DRB1*04 | Indian | [100] | |
|
|
|||
| HLA-DRB1*1502-DPB1*0201 | Indian | [98] | |
|
|
|||
| HLA-DRB1*1502-DQB1*0601-DPB1*0201 | Indian | [98] | |
|
| |||
| IFNG | |||
|
| |||
| rs1861493-rs1861494 | Indian | [107] | |
|
| |||
| IFNGR1 | |||
|
| |||
| rs2234711-rs3799488 | Chinese | [113] | |
|
| |||
| MBL2 | |||
|
| |||
| rs11003125-rs7095891-rs7096206-rs1800450 | Chinese | [122] | |
|
|
|||
| rs7096206-rs1800450 | Chinese | [165] | |
|
| |||
| MCP1 | |||
|
| |||
| rs1024611-rs2857656-rs3917887 | Ghanaian | [126] | |
|
|
|||
| rs1024611-rs2857656 | Ghanaian | [123] | |
|
| |||
| NRAMP1/SLC11A1 | |||
|
| |||
| rs17235416-rs3731865-rs17221959 | Indian | [133] | |
| Peruvian | [136] | ||
| Iranian | [154] | ||
|
|
|||
| rs17235416-rs17221959 | Tunisian | [137] | |
|
| |||
| TLR2 | |||
|
| |||
| rs4696480-rs3804099-rs5743699 | Moroccan | [145] | |
|
|
|||
| rs4696480-rs1898830-(-196 to -174 ins/del)-rs3804100 | Taiwanese | [166] | |
|
| |||
| TLR4 | |||
|
| |||
| rs10116253-rs10759932-rs1927911-rs1927907-rs5030717-rs5030725 | Sudanese | [146] | |
|
|
|||
| rs7869402-rs1927906-rs7044464 | Sudanese | [146] | |
|
| |||
| TNFA | |||
|
| |||
| HLA-B17- rs361525 | Indian | [167] | |
|
|
|||
| HLA-B17- rs1800629 | Indian | [167] | |
|
|
|||
| rs1800629-rs361525 | Colombian | [153] | |
|
| |||
| VDR | |||
|
| |||
| rs2228570-rs1544410-rs7975232-rs731236 | Indian | [162] | |
| Moroccan | [145] | ||
| South African | [103] | ||
|
|
|||
| rs2228570- rs1544410-rs7975232 | Indian | [162] | |
|
|
|||
| rs1544410-rs7975232-rs731236 | Indian | [162] | |
| Indian | [164] | ||
|
|
|||
| rs1544410-rs7975232 | Indian | [162] | |
|
|
|||
| rs2228570-rs1544410 | Indian | [162] | |