Table 1. Drug classes with target gene sets associated with GDM and DM2.

Of 129 drugs, representing 65 classes, 11 classes had adjusted P < 0.05 and are shown. L-type calcium channel blockers, represented by nifedipine, had the strongest P, which remained significant after adjusted for multiple comparisons. Examples and usual indication are shown. The number of genes is the number of genes targeted by the drug which had at least 1 SNP tested.

Class	Example	Indication	Genes	P
L-type calcium channel blocker	nifedipine	Hypertension	5	1.50E-04
NMDA receptor blockers	memantine	Alzheimer dementia	2	4.91E-04
Alpha blockers	prazosin	Hypertension	2	6.27E-03
Alpha/beta blockers	carvedilol	Hypertension	4	9.62E-03
Beta blockers	labetalol	Hypertension	4	9.62E-03
Sodium channel blocker	mexiletine	Arrhythmia	1	1.16E-3
Phosphodiesterase inhibitors	sildenafil	Pulmonary hypertension	1	1.18E-02
5HT-3 blockers	ondansetron	Nausea/vomiting	4	1.57E-02
PPARa activator	clofibrate	High cholesterol	1	2.12E-02
D2 blocker	metoclopramide	Nausea/vomiting	8	2.60E-02