Table 2. Multivariate regression of impact of drugs and their usual indication on GTT.

ΔGTT indicates the change in the value of the GTT attributable to the medication.

		Effect of drug
Class	Example(s)	Indication	ΔGTT (mg/dL)	95% CI (mg/dL)	P
L-type calcium channel blocker	nifedipine	Hypertension	−3.18	−6.18 to −0.18	0.038
Alpha 2 agonists	clonidine, methyldopa	Hypertension	−2.90	−7.45 to 1.65	0.211
Beta blockers	labetalol	Hypertension	3.14	−2.59 to 8.87	0.283
Alpha/beta blockers	carvedilol	Hypertension	0.72	−8.25 to 9.69	0.876
5HT-3-antagonists	ondansetron	Nausea/vomiting	3.54	1.86 to 5.23	< 0.001
D2 antagonist	metoclopramide	Nausea/vomiting	0	−2.38 to 2.38	0.998
5HT-1a partial agonist	buspirone	Anxiety	−6.48	−11.89 to −1.07	0.019
SNRIs	duloxetine	Depression/Anxiety	1.24	−2.75 to 5.23	0.543
NDRI	bupropion	Depression	−2.06	−5.32 to 1.21	0.217
SARIs	trazodone	Depression/Anxiety	−1.45	−5.79 to 2.89	0.512
NASSA	mirtazapine	Depression/Anxiety	6.13	−1.57 to 13.83	0.118
TCAs	amitriptyline	Depression/Anxiety	−0.31	−3.69 to 3.07	0.858
Biguanide	metformin	Diabetes	5.65	2.49 to 8.81	< 0.0001
Insulins	insulin aspart	Diabetes	19.62	15.93 to 23.31	< 0.0001
Sulfonylurea	glyburide	Diabetes	40.78	37.76 to 43.81	< 0.0001

Terms: GTT, 1 hour 50-gram glucose tolerance test; SNRI: serotonin-norepinephrine reuptake inhibitor, NDRI: norepinephrine-dopamine reuptake inhibitor, SARI: serotonin antagonist and reuptake inhibitor, NASSA: norepinephrine and selective serotonin agonist, TCA: tricyclic antidepressant.