Table 3.

Linear Model-Based and Change Point Model-Based Estimates of Cognitive Decline (CD measured in SD units per year) Among African Americans and European American Participants With No Cognitive Impairment, and Developing AD Dementia and MCI

	African Americans	European Americans
	Coefficient (95% CI)	Coefficient (95% CI)
Pre-change point AD dementia level	0.316 (0.228, 0.404)	0.274 (0.193, 0.354)
Pre-change point MCI level	0.139 (0.068, 0.209)	0.095 (0.033, 0.159)
Linear model-based estimates
CD – no cognitive impairment	0.016 (0.012, 0.020)	0.021 (0.017, 0.025)
CD – developing ad dementia	0.090 (0.080, 0.100)	0.157 (0.139, 0.174)
CD – developing MCI	0.034 (0.028, 0.040)	0.051 (0.043, 0.059)
Change point model-based estimates
Time of change prior to ad dementia	4.3 (3.9, 4.7) y	4.7 (4.3, 5.1) y
CD – before AD dementia change point	0.013 (0.009, 0.017)	0.020 (0.016, 0.024)
CD – after AD dementia change point	0.171 (0.153, 0.189)	0.233 (0.209, 0.256)
CD – after developing AD dementia	0.150 (0.119, 0.181)	0.224 (0.177, 0.271)
Time of change prior to MCI	3.6 (3.3, 3.9) y	3.0 (2.7, 3.3) y
CD – before MCI change point	0.011 (0.007, 0.015)	0.021 (0.017, 0.025)
CD – after MCI change point	0.084 (0.068, 0.099)	0.102 (0.084, 0.119)
CD – after developing MCI	0.091 (0.068, 0.115)	0.107 (0.076, 0.138)

Note: AD = Alzheimer’s disease; CD = cognitive decline; MCI = mild cognitive impairment.