Table 2.

Comparison of secukinumab versus placebo at week 16 for prespecified hierarchical endpoints

	Secukinumab 300 mg with LD (n=222)	Secukinumab 150 mg with LD (n=220)	Secukinumab 150 mg without LD (n=222)	Placebo (n=332)
Primary endpoint
ACR20 response (%)	62.6***	55.5***	59.5***	27.4
Prespecified secondary endpoints
vdH-mTSS structural progression (mean change from BL)†	0.08**	0.17*	−0.09*	0.50
PASI 75 response (%)‡	70.0*	60.0*	58.1*	12.3
PASI 90 response (%)‡	53.6*	36.8*	31.6*	9.3
ACR50 response (%)	39.6*	35.9*	32.0*	8.1
HAQ-DI score (LS mean change from BL)	−0.55*	−0.44*	−0.45*	−0.21
DAS28-CRP score (LS mean change from BL)	−1.49*	−1.29*	−1.29*	−0.63
Enthesitis resolution (%)§	55.7*	54.6*	41.9	35.4
Dactylitis resolution (%)¶	65.9*	57.5*	56.3	32.3

*P<0.05; **p<0.01; ***p<0.0001 unadjusted p values versus placebo are shown for endpoints that were significant in the hierarchical testing.

†Week 24 data.

‡Data from patients with baseline psoriasis affecting ≥3 BSA.

§Data from patients with enthesitis at baseline.

¶Data from patients with dactylitis at baseline.

ACR20, American College of Rheumatology 20; BL, baseline; BSA, body surface area; DAS28-CRP, 28-joint Disease Activity Score using C reactive protein; HAQ-DI, Health Assessment Questionnaire-Disability Index; LD, loading dose; LS, least squares; PASI, Psoriasis Area and Severity Index; vdH-mTSS, van der Heijde-modified total Sharp score.