Table 3.

Associations of physical activity at age 11 years with chronic disabling fatigue (CDF) at age 16 years

		Raw data (n=3907)	Imputed data (n=13 978)*
Total physical activity†	Unadjusted OR	0.87 (0.72, 1.04)	0.88 (0.74, 1.05)
	Partially adjusted OR‡	0.91 (0.76, 1.10)	0.91 (0.76, 1.09)
	Fully adjusted OR§	–	0.94 (0.77, 1.15)
	Fully adjusted mean difference (counts/min)§		−14.7 (−70.8, 41.4)
Moderate-to-vigorous physical activity¶	Unadjusted OR	0.89 (0.76, 1.06)	0.90 (0.78, 1.04)
	Partially adjusted OR‡	0.95 (0.80, 1.13)	0.94 (0.81, 1.09)
	Fully adjusted OR§	–	0.96 (0.82, 1.13)
	Fully adjusted mean difference (min/day)§		−0.82 (−5.48, 3.85)
Sedentary time**	Unadjusted OR	1.20 (0.94, 1.52)	1.23 (0.97, 1.56)
	Partially adjusted OR‡	1.17 (0.92, 1.49)	1.22 (0.96, 1.54)
	Fully adjusted OR§	–	1.16 (0.89, 1.51)
	Fully adjusted mean difference (min/day)§		12.6 (−9.76, 35.0)

*Variables for the multiple imputation (50 imputations) were as follows: CDF at 13 and 16 years; sex; nighttime sleep duration at 7 and 9 years; body mass index (BMI) at 7 and 9 years; child mood at 9 years (Short Moods and Feelings Questionnaire score); maternal depression at 6 years (Edinburgh Postnatal Depression Scale); maternal anxiety at 6 years (Crown-Crisp Experiential Index); mean test score for English, Mathematics and Science at 11 years (Key Stage 2 tests); maternal life events score (antenatal); self-esteem at 8 years (Global Self Worth subscale from Harter’s Self Perception Profile for Children); Avon Longitudinal Study of Parents and Children family adversity index (antenatal); family adversity index at 8–10 years; life difficulties, hyperactivity and internalising behaviour at 11 years (Strengths and Difficulties Questionnaire); screen time at 6 years; special school arrangements for emotional/behavioural problems at 7 years; conduct problems at 8 years; duration of breastfeeding; family income at 4 years; maternal childhood socioeconomic status; maternal education; maternal age at birth of child; maternal psychopathology at 8–10 years; experienced bullying at 8 years; days spent outdoors at 8 years; poor concentration at school at 7 years; maternal and paternal BMI at 8 years; internalising behaviour at 4 years (Strengths and Difficulties Questionnaire); early puberty; dietary patterns at 3  and 10 years.

†For total physical activity, change is per 100 counts/min increase in mean total physical activity for the whole week

‡Adjusted for sex and family adversity index (antenatal).

§Adjusted for sex; family adversity index (antenatal); BMI at 7 and 9 years; maternal depression at 6 years; maternal anxiety at 6 years; internalising behaviour at 4 and 11 years; self-esteem at 8 years; child mood at 9 years; early puberty; Key Stage 2 test scores; duration of breastfeeding; family income at 4 years; screen time at 6 years; maternal childhood socioeconomic status; maternal life events score (antenatal); nighttime sleep duration at 8 years; conduct problems at 8 years; dietary patterns at 10 years.

¶For moderate-to-vigorous physical activity, change is per 15 min increase (threshold ≥3500 counts/min).

**For sedentary time, change is per hour increase.